Reaktion #430923

Reaktionsgleichung

4-hydroxystyrene

tert-butyl bromoacetate

potassium carbonate

→

desired product

Ausbeute 93.2%

tert-Butyl (4-vinylphenoxy)acetate

Ausbeute 93.2%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe inorganic salts are removed by filtration
3. 3
   Einengenthe filtrate is concentrated
4. 4
   Waschenwashed twice with 800 ml of 1.0N sodium hydroxide solution
5. 5
   SonstigeThe organic phase is separated
6. 6
   Trocknendried over magnesium sulfate
7. 7
   Einengenconcentrated

Vorschrift

In a 1500 ml sulfonation flask, 135.6 g (1.13 mol) of 4-hydroxystyrene and 220.2 g (1.13 mol) of tert-butyl bromoacetate are dissolved in 800 ml of acetone and to the solution are added 195.0 g (1.41 mol) of potassium carbonate and 0.8 g of potassium iodide. The resultant suspension is stirred for 4 hours at 60° C. bath temperature. After cooling, the inorganic salts are removed by filtration and the filtrate is concentrated. The oily residue is taken up in 1000 ml of diethyl ether, washed twice with 800 ml of 1.0N sodium hydroxide solution and then three times with 1000 ml of water. The organic phase is separated, dried over magnesium sulfate and concentrated, giving 246.5 g of the desired product as a clear oil (93.2 %).

Quelle