Reaktion #4307

Reaktionsgleichung

hydrogen chloride

2-chloroethyl phenyl sulfone

3-ethoxy-1-propanamine

triethylamine

→

white crystalline solid

Ausbeute 63.2%

3-Ethoxy-N-[2-(phenylsulfonyl)ethyl]-1-propanamine hydrochloride

Ausbeute 63.2%

Lösungsmittel

methanol

ether

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe residue was partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   TrocknenThe methylene chloride phase was dried over magnesium sulfate
4. 4
   Sonstigethe solvent was removed in vacuo
5. 5
   Sonstigeto give an oil
6. 6
   SonstigeA precipitate was collected

Vorschrift

A mixture of 51.4 g (0.253 mole) of 2-chloroethyl phenyl sulfone, 50.2 g (0.417 mole) of 3-ethoxy-1-propanamine, and 33.0 g (0.327 mole) of triethylamine in 400 ml of acetonitrile was stirred at room temperature for 20 hr. The solvent was removed in vacuo and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride phase was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, an excess of ethereal hydrogen chloride was added and ether was added. A precipitate was collected to give 49.2 g (63.2%) of white crystalline solid, m.p. 169°-170° C.

Quelle