Reaktion #43061

Reaktionsgleichung

Intermediate 1

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HCl dioxane

trimethylorthoformate

→

2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by rotary evaporation
2. 2
   Sonstigeto give product, which

Vorschrift

Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.

Quelle