Reaktion #43056

Reaktionsgleichung

Intermediate 24

4-{2-[4-(3-Amino-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

3-tert-butoxycarbonylamino-propionic acid

→

3-Amino-N-(3-{2-[2-(4-hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-propionamide

Reaktionsbedingungen

Vorschrift

Intermediate 24 was coupled to 3-tert-butoxycarbonylamino-propionic acid by procedure K. The resulting product was deprotected by procedure G. LC-MS showed the product had the expected M+H+ of 377. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.6 (d, 1H) 8.4 (d, 1H) 8.1 (s, 1H) 7.8 (d, 1H) 7.5 (t 3H), 7.2 (d, 1H), 7.1 (d, 2H), 6.7 (d 2H), 3.6 (d, 2H), 3.1 (d, 2H), 2.8 (d, 2H), 2.5 (d, 2H).

Quelle