Reaktion #4303

Reaktionsgleichung

Ether

benzyl 2-chloroethyl sulfone

isopropylamine

hydrogen chloride

→

white crystalline solid

Ausbeute 65.8%

N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

Ausbeute 65.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe residue was partitioned between ether and dilute sodium hydroxide
3. 3
   TrocknenThe ether solution was dried over magnesium sulfate
4. 4
   Sonstigethe solvent was removed in vacuo
5. 5
   Sonstigeto give an oil
6. 6
   Sonstigea white solid precipitated

Vorschrift

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

Quelle