Reaktion #43023

ord-1fc235b6f85a43b4a99287ff419e95a2

Reaktionsgleichung

Nc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 6
Nc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-phenylamine
CC(C)(C)OC(=O)N1CCC(=O)C1
3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CCC(Nc2cccc(-c3ccnc(Cl)n3)c2)C1
3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
Ausbeute 70.0%

Edukte

Nc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 6
Nc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-phenylamine
CC(C)(C)OC(=O)N1CCC(=O)C1
3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was purified on silica gel using 1:1 ethyl acetate

Vorschrift

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732444B2uspto-grants-2010_06