Reaktion #4300

Reaktionsgleichung

ether

2-chloroethylphenylsulfone

phenethylamine

triethylamine

→

white crystalline solid

Ausbeute 89.1%

N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate

Ausbeute 89.1%

Lösungsmittel

methanol

hydrogen chloride

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe residue was partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   TrocknenThe methylene chloride solution was dried over magnesium sulfate
4. 4
   Sonstigethe solvent was removed in vacuo
5. 5
   Sonstigeto give an oil
6. 6
   workup.ADDITIONwas added
7. 7
   SonstigeA white solid precipitated

Vorschrift

A mixture of 70.23 g (0.344 mole) of 2-chloroethylphenylsulfone, 41.92 g (0.343 mole) of phenethylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol and excess of ethereal hydrogen chloride was added and ether was added. A white solid precipitated to give 68.39 g (60%) of white crystalline solid, m.p. 194°-196° C.

Quelle