Reaktion #42971

Reaktionsgleichung

Phenylenediamine

Triethylamine

thiophosgene

solution

2-(4-Amino-6,8-dimethoxy-isoquinolin-1-ylmethyl)-isoindole-1,3-dione

→

title compound

Ausbeute 50.6%

(1-Aminomethyl-6,8-dimethoxy-isoquinolin-4-yl)-(1H-benzoimidazol-2-yl)-amine

Ausbeute 50.6%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenOrganics were washed with 0.5 N HCl and brine
2. 2
   Trocknendried (MgSO4)
3. 3
   Einengenconcentrated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in DMF (5 mL)
5. 5
   workup.STIRRINGthe reaction stirred at 90° C. for 2 h
6. 6
   workup.STIRRINGthe reaction stirred for 3 h longer before it
7. 7
   Einengenwas concentrated in vacuo
8. 8
   workup.WAITDeprotection was carried out in ethanol (5 mL) with hydrazine (0.2 mL) at r.t. for 1 h
9. 9
   SonstigePurification by Prep-HPLC

Vorschrift

Triethylamine (210 μL, 1.52 mmol) and then thiophosgene (55 μL, 0.72 mmol) were added to a solution of Example 45C (200 mg, 0.55 mol) in dichloromethane (5 mL), and the reaction stirred 1 h at r.t. Organics were washed with 0.5 N HCl and brine, dried (MgSO4), and concentrated. The residue was dissolved in DMF (5 mL). Phenylenediamine (89 mg, 0.82 mmol) was added, and the reaction stirred at 90° C. for 2 h. Mercury(II) oxide was added, and the reaction stirred for 3 h longer before it was concentrated in vacuo. Deprotection was carried out in ethanol (5 mL) with hydrazine (0.2 mL) at r.t. for 1 h. Purification by Prep-HPLC gave 145 mg (46%) of the title compound (TFA salt) as a yellow solid. H1-NMR (MeOD-d4): δ 8.61 (s, 1H), 7.38-7.42 (m, 2H), 7.30-7.34 (m, 2H), 7.23 (s, 1H); 7.02 (d, 1H, J=2.0 Hz), 6.89 (d, 1H, J=2.0 Hz), 4.92 (s, 2H), 4.01 (s, 3H), 3.91 (s, 3H). MS (ES) (M+H) calc'd for C19H19N5O2, 350; found 350.

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