Reaktion #429691

Reaktionsgleichung

4,6-dichloro-5-methoxypyrimidine

2-(4-chlorophenyl)ethanol

sodium hydride

ammonium chloride

hydrogen

→

4-[2-(4-chlorophenyl)ethoxy]-5-methoxy-6-chloropyrimidine

Ausbeute 88.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITION96, 1661 (1965) were added in portions
2. 2
   Extraktionextracted with diethyl ether
3. 3
   TrocknenThe combined organic phase was dried over magnesium sulfate
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe residue was chromatographed on silica gel

Vorschrift

2.40 g (15.2 mmol) of 2-(4-chlorophenyl)ethanol were added dropwise at 40° C. to a suspension of 680 mg (22.7 mmol) of sodium hydride (80% suspension in oil) in 40 ml of dry tetrahydrofuran, and the mixture was stirred until the evolution of hydrogen had ceased. The mixture was then allowed to cool to room temperature, whereupon 2.7 g (15.2 mmol) of 4,6-dichloro-5-methoxypyrimidine (Monatshefte Chem. 96, 1661 (1965) were added in portions. The mixture was stirred for 1 hour at room temperature and for 4 hours at 40° C. For work-up, the reaction mixture was poured into saturated ammonium chloride solution and extracted with diethyl ether. The combined organic phase was dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel using n-heptane/ethyl acetate (4:1). 4.0 g (88% of theory) of 4-[2-(4-chlorophenyl)ethoxy]-5-methoxy-6-chloropyrimidine was obtained in the form of a viscous oil which crystallized slowly upon drying (melting point 70°-71° C.).

Quelle