Reaktion #429379

Reaktionsgleichung

(E)-1,4-dibromobutene

3-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene

N-allyl-methyl-amine

→

3-(4-bromo-phenyl)-benzo[b]thiophen-6-ol

6-(4-(E)-bromo-but-2-enyloxy)-3-(4-bromo-phenyl)-benzo[b]thiophene

(E)-allyl-[4-[3(4-bromo-phenyl)-benzo[b]thiopen-6-yloxy]-but-2-enyl]-methyl-amine

Reaktionsbedingungen

Vorschrift

Analogously to Example 3, from 3-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene (Ex. 3b), after cleavage of the methoxy protecting group, reaction with (E)-1,4-dibromobutene and N-allyl-methyl-amine and salt formation, via 3-(4-bromo-phenyl)-benzo[b]thiophen-6-ol und via 6-(4-(E)-bromo-but-2-enyloxy)-3-(4-bromo-phenyl)-benzo[b]thiophene there is obtained (E)-allyl-[4-[3(4-bromo-phenyl)-benzo[b]thiopen-6-yloxy]-but-2-enyl]-methyl-amine.fumarat (1:1), MS: m/e 428 (M+H+, Br).

Quelle