Reaktion #429356

Reaktionsgleichung

ethyl bromide

magnesium

ethyl oxalate

1-bromo-2-(1-ethoxyethyl)oxymethylbenzene

→

ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate

Ausbeute 68.4%

Lösungsmittel

THF

THF

water

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprepared
2. 2
   workup.ADDITIONAfter completion of the addition
3. 3
   TemperaturAfter cooling
4. 4
   workup.STIRRINGThen, the mixture was stirred at -50° to -60° C. for 1 hour
5. 5
   workup.ADDITIONwas added
6. 6
   Extraktionthe mixture was extracted with ether (200 ml)
7. 7
   TrocknenThe extract was dried over anhydrous magnesium sulfate
8. 8
   Einengenconcentrated under reduced pressure
9. 9
   SonstigeThe resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane)

Vorschrift

A mixed solution of 1-bromo-2-(1-ethoxyethyl)oxymethylbenzene (3.11 g, 0.012 mol) and dry THF (10 ml) was added dropwise at 50° to 60° C. over 25 minutes to a solution prepared by adding dry THF (2 ml) and ethyl bromide (0.2 ml) to magnesium (0.44 g, 0.018 mol) in a stream of nitrogen. After completion of the addition, the mixture was stirred at 50° to 60° C. for 1 hour and cooled to room temperature. After cooling, the mixture was added dropwise to a mixed solution of ethyl oxalate (2.63 g, 0.018 mol) and dry THF (30 ml) at below -50° C. over 15 minutes. Then, the mixture was stirred at -50° to -60° C. for 1 hour. After completion of the reaction, water (200 ml) was added, and the mixture was extracted with ether (200 ml). The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate (2.30 g, Yield: 68.4%) as a colorless oil.

Quelle