Reaktion #429355

Reaktionsgleichung

3,4-dihydro-2H-pyrane

2-bromobenzyl alcohol

sodium bicarbonate

→

1-bromo-2-(2-tetrahydropyranyloxymethyl)benzene

Ausbeute 99.3%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter the resulting mixture was stirred at room temperature for 2 hours
2. 2
   ExtraktionThe mixture was extracted with dichloromethane (200 ml)
3. 3
   TrocknenAfter the mixture was dried over anhydrous magnesium sulfate
4. 4
   Sonstigethe solvent was evaporated

Vorschrift

Pyridinium p-toluenesulfonate (0.30 g, 0.0012 mol) was added to a solution of 2-bromobenzyl alcohol (25 g, 0.134 mol) in dichloromethane (100 ml), and the mixture was stirred at room temperature. To this mixture was added 3,4-dihydro-2H-pyrane (16.86 g, 0.20 mol). After the resulting mixture was stirred at room temperature for 2 hours, a saturated aqueous solution (200 ml) of sodium bicarbonate was added. The mixture was extracted with dichloromethane (200 ml). After the mixture was dried over anhydrous magnesium sulfate, the solvent was evaporated to obtain the desired compound 1-bromo-2-(2-tetrahydropyranyloxymethyl)benzene (36.00 g, Yield: 99.3%) as an oil.

Quelle