Reaktion #429354

Reaktionsgleichung

2-bromobenzyl alcohol

ethyl vinyl ether

sodium bicarbonate

→

1-bromo-2-(1-ethoxyethyl)oxymethyl-benzene

Ausbeute 98.2%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   SonstigeAfter completion of the reaction
3. 3
   Extraktionthe mixture was extracted with dichloromethane (100 ml) twice
4. 4
   TrocknenThe extract was dried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

Pyridinium p-toluenesulfonate (0.50 g, 0.002 mol) was added to a mixed solution of 2-bromobenzyl alcohol (18.70 g, 0.1 mol), dichloromethane (150 ml) and ethyl vinyl ether (14.42 g, 0.2 mol) under ice-cooling, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, a half-saturated aqueous solution (300 ml) of sodium bicarbonate was added, and the mixture was extracted with dichloromethane (100 ml) twice. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 1-bromo-2-(1-ethoxyethyl)oxymethyl-benzene (25.44 g, Yield: 98.2%) as a colorless oil.

Quelle