Reaktion #429290

ord-8e4c4d46ed524b0e9eb8de17e594afa0

Reaktionsgleichung

C[Si](C)(C)Cl
chlorotrimethylsilane
N[C@@H](CCC(=O)O)C(=O)O
L-Glutamic acid
C=CCO
allyl alcohol
→
C=CCOC(=O)CCC(N)C(=O)O
2-amino-pentanedioic acid 5-allyl ester
Ausbeute 62.0%

Edukte

C[Si](C)(C)Cl
chlorotrimethylsilane
N[C@@H](CCC(=O)O)C(=O)O
L-Glutamic acid
—
γ-allyl ester
C=CCO
allyl alcohol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

L-Glutamic acid (3) was protected in 62% yield as the γ-allyl ester using allyl alcohol and chlorotrimethylsilane to provide 2-amino-pentanedioic acid 5-allyl ester 4 as follows:

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05856506uspto-grants-1999_01