Reaktion #429093

Reaktionsgleichung

4-(5,6-dimethoxybenzothiazolyl)benzoic acid

isobutyl chloroformate

ethyl diisopropylamine

6-aminohexanol

→

Compound ( 2 )

5-amino-1,10-phenanthroline

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGby stirring for 1 hour
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   Sonstigethe residue was purified by silica gel column chromatography

Vorschrift

In 20 ml of dimethylformamide was dissolved 0.26 g (0.8 mmol) of Compound (1), which is 4-(5,6-dimethoxybenzothiazolyl)benzoic acid. Further, 0.12 ml (0.9 mmol) of isobutyl chloroformate and 0.16 ml (0.9 mmol) of ethyl diisopropylamine were added thereto, followed by stirring at room temperature for 1 hour. Then, 0.10 g (0.9 mmol) of 6-aminohexanol was added thereto, followed by stirring for 1 hour and a half. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 0.15 g of Compound (2).

Quelle