Reaktion #42897

ord-97d98d3be3ea433fbff47711219bf1d3

Reaktionsgleichung

COC(=O)c1cscc1N
4-amino-thiophene-3-carboxylic acid methyl ester
O=C(Cl)C(F)(F)Cl
chlorodifluoroacetyl chloride
Oc1ccc(-c2ccc(F)cc2)cc1
4-fluoro-4′-hydroxybiphenyl
→
O=C(O)c1cscc1NC(=O)C(F)(F)Oc1ccc(-c2ccc(F)cc2)cc1
title compound
O=C(O)c1cscc1NC(=O)C(F)(F)Oc1ccc(-c2ccc(F)cc2)cc1
Rac-4-[2,2-Difluoro-2-(4′-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid

Edukte

COC(=O)c1cscc1N
4-amino-thiophene-3-carboxylic acid methyl ester
O=C(Cl)C(F)(F)Cl
chlorodifluoroacetyl chloride
Oc1ccc(-c2ccc(F)cc2)cc1
4-fluoro-4′-hydroxybiphenyl

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to Example 58, the title compound was prepared using 4-amino-thiophene-3-carboxylic acid methyl ester, chlorodifluoroacetyl chloride and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 406.1 (M−H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732452B2uspto-grants-2010_06