Reaktion #42892

ord-b040bc29c3e64f11820358c03ca818b1

Reaktionsgleichung

COC(=O)c1cscc1NC(=O)C(C)Cl
rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester
CC(C)(C)c1ccc(O)cc1
4-tert-butylphenol
→
CC(Oc1ccc(C(C)(C)C)cc1)C(=O)Nc1cscc1C(=O)O
title compound
CC(Oc1ccc(C(C)(C)C)cc1)C(=O)Nc1cscc1C(=O)O
Rac-4-[2-(4-tertButyl-phenoxy)-propionylamino]-thiophene-3-carboxylic acid

Edukte

COC(=O)c1cscc1NC(=O)C(C)Cl
rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester
CC(C)(C)c1ccc(O)cc1
4-tert-butylphenol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to Example 2, the title compound was prepared using rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester and 4-tert-butylphenol. MS (m/e): 346.2 (M−H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732452B2uspto-grants-2010_06