Reaktion #4288

Reaktionsgleichung

methanesulfonic acid[2-[(3,4-dichlorophenyl)thio]ethyl]ester

isopropylamine

→

title compound

N-[2-[(3,4-Dichlorophenyl)thio]ethyl]-2-propanamine, hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe isopropylamine was removed in a rotary evaporator
2. 2
   Sonstigethe residue partitioned between chloroform and 5% sodium hydroxide
3. 3
   SonstigeThe chloroform was removed by rotary evaporator
4. 4
   Sonstigeto give an oil

Vorschrift

A solution of 151.46 g (0.548 mole) of methanesulfonic acid[2-[(3,4-dichlorophenyl)thio]ethyl]ester in 100 ml of isopropylamine was heated overnight in a bomb at 100° C. The isopropylamine was removed in a rotary evaporator and the residue partitioned between chloroform and 5% sodium hydroxide. The chloroform was removed by rotary evaporator to give an oil, the free base of the title compound. The oil was dissolved in methanol and converted to the hydrochloride salt with ethereal hydrogen chloride. Recrystallization of the salt from methanol-diethyl ether gave 101.53 g (61.6%) of white crystalline product, m.p. 132°-133.5° C.

Quelle