Reaktion #426920

Reaktionsgleichung

1,2-Dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid

3-(4-(3-chlorophenyl) piperazin-1-yl)propan-1-amine dihydrochloride

EDCI

HOBT

NMM

→

title compound

Ausbeute 71.8%

N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide

Ausbeute 71.8%

Lösungsmittel

MeOH

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfilter off
2. 2
   SonstigeAfter evaporation under reduced pressure
3. 3
   Sonstigethe residue was purified by reverse phase preparative HPLC

Vorschrift

To the mixture of 1,2-Dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid (100 mg, 0.46 mmol) and 3-(4-(3-chlorophenyl) piperazin-1-yl)propan-1-amine dihydrochloride (152 mg, 0.46 mmol) in methylene chloride (5 ml) was added EDCI (178 mg, 0.92 mmol), HOBT (130 mg, 0.9 mmol) and NMM (0.3 ml, 1.8 mmol) continuously. After stirring for 1 day at room temperature, MeOH was added to the resulting solution, and filter off. After evaporation under reduced pressure, the residue was purified by reverse phase preparative HPLC to provided title compound (149 mg, 71%) as white solid.

Quelle