Reaktion #426780

Reaktionsgleichung

2-(2-fluoroethoxy)-4-nitrobenzaldehyde

sodium hydride

DCM MeOH

4-(6-methylimidazo[1,2-a]pyridin-2-yl)benzyl phosphonate

→

title compound

Ausbeute 74.6%

2-(4-{(E)-2-[4-nitro-2-(2-fluoroethoxy)phenyl]ethenyl}phenyl)-6-methylimidazo[1,2-a]pyridine

Ausbeute 74.6%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrepared

Vorschrift

Prepared as described in the Alkene Formation section using sodium hydride (60% dispersion in mineral oil, 27 mg, 0.67 mmol), diethyl[4-(6-methylimidazo[1,2-a]pyridin-2-yl)benzyl phosphonate (200 mg, 0.559 mmol) and 2-(2-fluoroethoxy)-4-nitrobenzaldehyde (119 mg, 0.559 mmol) in dry THF (15 ml) to give the title compound (174 mg, 74%) as an orange solid after work-up and flash chromatography (50:1 DCM/MeOH).

Quelle