Reaktion #426738

Reaktionsgleichung

6-fluoro-2-(4-nitrophenyl)imidazo[1,2-a]pyridine

EtOAc DCM

tin (II) dichloride dihydrate

→

title compound

Ausbeute 82.0%

4-(6-Fluoroimidazo[1,2-a]pyridin-2-yl)aniline

Ausbeute 82.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrepared

Vorschrift

Prepared as described in the Nitro Reduction section using 6-fluoro-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (0.45 g, 1.75 mmol) and tin (II) dichloride dihydrate (1.97 g, 8.75 mmol) in EtOH (25 ml) to give the title compound (0.325 g, 82%) as a pale yellow solid after work-up and flash chromatography (4:1 EtOAc/DCM).

Quelle