Reaktion #426200

Reaktionsgleichung

(R)-tert-butyl 1-benzyl-3-(hydroxymethyl)pyrrolidin-3-ylcarbamate

ammonium formate

→

(R)-tert-butyl 3-(hydroxymethyl)pyrrolidin-3-ylcarbamate

Ausbeute 95.4%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux under nitrogen for 3 hours
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe reaction mixture was filtered through Celite®
5. 5
   EinengenThe filtrate was concentrated under reduced pressure
6. 6
   Filtrationfiltered through Celite again
7. 7
   SonstigeRemoval of the solvent

Vorschrift

A mixture of (R)-tert-butyl 1-benzyl-3-(hydroxymethyl)pyrrolidin-3-ylcarbamate (387 mg, 1.26 mmol), 10% Pd/C (134 mg, 0.126 mmol), ammonium formate (398 mg, 6.32 mmol) and MeOH (10 mL) was heated at reflux under nitrogen for 3 hours. After cooling, the reaction mixture was filtered through Celite®. The filtrate was concentrated under reduced pressure. The residue was taken up in DCM and filtered through Celite again. Removal of the solvent gave (R)-tert-butyl 3-(hydroxymethyl)pyrrolidin-3-ylcarbamate (260 mg, 95%), which was used in the next Step without further purification.

Quelle