Reaktion #42613

Reaktionsgleichung

methanesulfonyl chloride

ethyl 2-amino-1,3-oxazole-4-carboxylate

N,N-diisopropylethylamine

→

ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 20 ml screw cap
2. 2
   SonstigeThe reaction was then evaporated to dryness
3. 3
   Sonstigepurified
4. 4
   Sonstigeresulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

Vorschrift

To a 20 ml screw cap vial was added (1 g, 5.8069 mmoles) ethyl 2-amino-1,3-oxazole-4-carboxylate, (10 ml) dichloromethane and (1.39 ml, 7.9797 mmoles, 1.25 eq.) N,N-diisopropylethylamine. To the reaction was then added (0.545 ml, 7.0415 mmoles, 1.1 eq.) methanesulfonyl chloride, and the reaction was agitated for 14 hours. The reaction was then evaporated to dryness and purified using a Biotage silica gel column, resulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate.

Quelle