Reaktion #42560

Reaktionsgleichung

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester

HCl

dioxane

methanol

→

solid

Ausbeute 106.0%

BOC-acetylene

Ausbeute 106.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles were evaporated in vacuo
2. 2
   workup.ADDITIONDioxane (20 mL) was added
3. 3
   Sonstigethe mixture was evaporated in vacuo

Vorschrift

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester (2.34 g, 5.13 mmol) was treated with 4N HCl in dioxane (15.8 mL, 63.3. mmol). The resulting heterogeneous mixture was treated with methanol (10 mL) whereupon it became homogeneous over 30 min. The volatiles were evaporated in vacuo. Dioxane (20 mL) was added and the mixture was evaporated in vacuo to produce a white solid (2.33 g, 106%).

Quelle