Reaktion #42537

Reaktionsgleichung

7-bromo-1-chloroisoquinoline

dipropylamine

→

7-bromo-N,N-dipropylisoquinolin-1-amine

Ausbeute 62.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled
2. 2
   Sonstigethe solvent was removed under reduced pressure

Vorschrift

A solution of 7-bromo-1-chloroisoquinoline from step 1 (500 mg, 2.1 mmol) and dipropylamine (2.8 mL, 21 mmol) was heated at 150° C. in a sealed tube for 2 d. The reaction mixture was cooled, and the solvent was removed under reduced pressure to provide 7-bromo-N,N-dipropylisoquinolin-1-amine (400 mg): 1H NMR (300 MHz, DMSO-d6) δ 8.55 (s, 1H), 7.90 (d, J=6 Hz, 1H), 7.75-7.64 (m, 2H), 6.87 (d, J=6 Hz, 1H), 3.42 (q, J=7 Hz, 4H), 1.65 (q, J=7 Hz, 4H), 0.94 (t, J=7 Hz, 6H).

Quelle