Reaktion #424901

Reaktionsgleichung

1,2-epoxycycloheptane

1-methylpyrazole

N,N,N′,N′-tetramethylethylenediamine

n-butyl lithium

→

title compound

Ausbeute 13.0%

(1S*,2R*)-2-(1-Methyl-1H-pyrazol-5-yl)cycloheptanol

Ausbeute 13.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction and aftertreatment

Vorschrift

The reaction and aftertreatment were conducted in the same manner as in Example 4a by using 1-methylpyrazole (3.66 g, 44.6 mmol), N,N,N′,N′-tetramethylethylenediamine (6.68 mL, 44.6 mmol), n-butyl lithium (1.63 M solution in hexane; 32 mL, 52.2 mmol), 1,2-epoxycycloheptane (5.0 g, 44.6 mmol) and THF (60 mL), to yield the title compound (1.13 g, 13%) as a colorless oil.

Quelle