Reaktion #424884

Reaktionsgleichung

trifluoroacetic acid

chlorodicyclohexylphosphine

n-Butyllithium

benzenesulfonic acid

→

compound 1a

2-(dicyclohexylphosphino)benzenesulfonic acid

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the reaction container to −78° C.
2. 2
   workup.STIRRINGat −78° C. and stirred for 24 hours at room temperature
3. 3
   Sonstigethe precipitate formed
4. 4
   Filtrationwas collected by filtration
5. 5
   Sonstigedried under reduced pressure

Vorschrift

n-Butyllithium (manufactured by Kanto Chemical Co., Inc., 1.65 M hexane solution, 5.1 ml, 8.4 mmol) was added to a tetrahydrofuran (THF) solution (20 ml) of benzenesulfonic acid (manufactured by Tokyo Chemical Industry Co., Ltd., 0.66 g, 4.2 mmol) at 0° C. under argon atmosphere and the mixture was stirred for 2.5 hours at room temperature. After cooling the reaction container to −78° C., chlorodicyclohexylphosphine (manufactured by Sigma-Aldrich, 0.89 mg, 3.8 mmol) was added thereto at −78° C. and stirred for 24 hours at room temperature. After ceasing the reaction with trifluoroacetic acid (manufactured by Tokyo Chemical Industry Co., Ltd., 0.50 M THF solution, 8.4 ml, 4.2 mmol), the precipitate formed was collected by filtration and dried under reduced pressure to obtain 2-(dicyclohexylphosphino)benzenesulfonic acid (compound 1a). The yield was 0.66 g (85%).

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