Reaktion #424580

ord-c2e3305fb560461db910a7b100420e5b

Reaktionsgleichung

O
water
O=P(Cl)(Cl)CP(=O)(Cl)Cl
methylenebis(phosphonic dichloride)
O=C(c1ccccc1)c1ccc(O)cc1
4-hydroxybenzophenone
c1ccncc1
pyridine
→
O=C(c1ccccc1)c1ccc(CP(=O)(Cl)Cl)cc1
(4-benzoylbenzyl)phosphonic dichloride

Edukte

O
water
O=P(Cl)(Cl)CP(=O)(Cl)Cl
methylenebis(phosphonic dichloride)
O=C(c1ccccc1)c1ccc(O)cc1
4-hydroxybenzophenone
c1ccncc1
pyridine

Reagenzien

Keine

Lösungsmittel

ClCCl
DCM

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeis formed

Vorschrift

A degradable linking agent is formed by reacting methylenebis(phosphonic dichloride) (1 eq) with 4-hydroxybenzophenone (2 eq) in anhydrous DCM using pyridine (2.5 eq) as a base. The resulting product can be converted into its salt to increase water solubility.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08889760B2uspto-grants-2014_11