Reaktion #423442

ord-8761c349e3134a7f85bf3a9876c2e5e3

Reaktionsgleichung

Cc1cc(C#N)cnc1F
5-cyano-2-fluoro-3-methylpyridine
CC1CCCCN1
2-methylpiperidine
→
Cc1cc(C#N)cnc1N1CCCCC1C
5-methyl-6-(2-methylpiperidin-1-yl)nicotinonitrile

Edukte

Cc1cc(C#N)cnc1F
5-cyano-2-fluoro-3-methylpyridine
CC1CCCCN1
2-methylpiperidine

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
90°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A mixture of 5-cyano-2-fluoro-3-methylpyridine (Molekula M52391889; 1.5 g; 11 mmol; 1 eq.) and 2-methylpiperidine (5.2 mL; 44.1 mmol; 4 eq.) was stirred at 90° C. for 16 hours.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08889668B2uspto-grants-2014_11