Reaktion #42335

ord-da90b0ae5963488daffc62f844ba69b8

Reaktionsgleichung

CCCC(CCC)S(=O)(=O)C[C@H](NC(C)=O)C(=O)OC
methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate
Cl
HCl
→
CCCC(CCC)S(=O)(=O)C[C@H](N)C(=O)O.Cl
3-[(1-propylbutyl)sulfonyl]alanine HCl salt

Edukte

CCCC(CCC)S(=O)(=O)C[C@H](NC(C)=O)C(=O)OC
methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate
Cl
HCl

Reagenzien

Keine

Lösungsmittel

CC(=O)O
acetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeA 250 ml round bottom flask equipped with magnetic stir bar
  2. 2
    Temperaturreflux condenser, and N2 inlet
  3. 3
    TemperaturThe solution was refluxed for 4 hours
  4. 4
    Einengenthen concentrated in vacuo
  5. 5
    Sonstigevacuum dried overnight

Vorschrift

A 250 ml round bottom flask equipped with magnetic stir bar, reflux condenser, and N2 inlet was charged with 9.2 g methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate in 50 ml acetic acid and 50 ml conc. HCl. The solution was refluxed for 4 hours then concentrated in vacuo. The residue was chased with toluene (2×) then vacuum dried overnight to yield 7.8 g of the desired 3-[(1-propylbutyl)sulfonyl]alanine HCl salt.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727997B2uspto-grants-2010_06