Reaktion #42304

ord-d7129d6dce2e450d859df2905d292e8c

Reaktionsgleichung

CCCN(CCC)C(=O)c1cc(C(N)=O)cc(C(=O)O)c1
3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid
CCCN(CCC)C(=O)c1cc(C(N)=O)cc(C(=O)O)c1
3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoic acid
COc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.O=C(O)C(F)(F)F
(2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol
COc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.O=C(O)C(F)(F)F
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol trifluoroacetate
→
CCCN(CCC)C(=O)c1cc(CO)cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)c1
title compound
CCCN(CCC)C(=O)c1cc(CO)cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)c1
N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamide

Edukte

CCCN(CCC)C(=O)c1cc(C(N)=O)cc(C(=O)O)c1
3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid
CCCN(CCC)C(=O)c1cc(C(N)=O)cc(C(=O)O)c1
3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoic acid
COc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.O=C(O)C(F)(F)F
(2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol
COc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.O=C(O)C(F)(F)F
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol trifluoroacetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of CHART P and Example 739 and making non-critical variations but using 3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid (IX) and (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII), the title compound is obtained, HRMS (FAB)=615.3571.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727997B2uspto-grants-2010_06