Reaktion #4219
ord-95fce6ee0fd6497e86db89788ce9af11
Reaktionsgleichung
Meta-cyanobenzaldehyde
1-(3-trifluoromethyl-4-chlorophenylamino)-2-butanol
water
→
2-m-Cyanophenyl-3-(3-trifluoromethyl-4-chlorophenyl)-5-ethyl oxazolidine
Reagenzien
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1workup.ADDITIONwas added
- 2Sonstigethe mixture was stripped on a rotary evaporator
Vorschrift
Meta-cyanobenzaldehyde (2.1 g, 0.016 mole) was added to 4.3 g of 1-(3-trifluoromethyl-4-chlorophenylamino)-2-butanol in 50 ml of toluene and 2-3 drops of methane sulfonic acid was added. The mixture was refluxed under a modified Dean-Stark apparatus until no more water came off and the mixture was stripped on a rotary evaporator. Yield was 6 g of product, nD30 1.5774. It was characterized by IR and NMR.