Reaktion #4218

Reaktionsgleichung

Meta-chlorobenzaldehyde

1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol

→

2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe mixture was heated on the steam bath for about one hour
3. 3
   Sonstigestripped on the rotary evaporator

Vorschrift

Meta-chlorobenzaldehyde (2.3 g, 0.016 mole) was combined with 5 g of 1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol and 3 drops of methane sulfonic acid was added. The mixture was heated on the steam bath for about one hour and stripped on the rotary evaporator. The product, a sticky, thick liquid, was characterized by IR and NMR.

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