Reaktion #421292

Reaktionsgleichung

4-methylpyrimidine-2-ylamine

N-bromosuccinimide

→

5-bromo-4-methylpyrimidine-2-ylamine

Ausbeute 87.4%

Lösungsmittel

DCM

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 1N NaOH aq solution and brine
2. 2
   Trocknendried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated

Vorschrift

To a solution of 4-methylpyrimidine-2-ylamine (8.0 g, 0.073 mol) in chloroform (320 mL) was added N-bromosuccinimide (13.7 g, 0.077 mol). The reaction mixture was stirred in the dark for 18 hrs. LC/MS indicated the reaction was completed. The mixture was diluted with DCM, then washed with 1N NaOH aq solution and brine, dried over MgSO4, filtered and concentrated to yield 5-bromo-4-methylpyrimidine-2-ylamine (12 g, Yield: 86%).

Quelle