Reaktion #42116

Reaktionsgleichung

2-chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile

isobutylamine

→

title compound

6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile

Reaktionsbedingungen

Vorschrift

2-chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile (prepared from 6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-1,2-dihydro-2-oxopyridine-3-carbonitrile using conditions similar to Step C Example 1) was reacted with isobutylamine using the conditions of Step A EXAMPLE 27 to afford the title compound. HPLC/MS: 414.1 (M+1), 415.9 (M+3); Rt=4.68 min.

Quelle