Reaktion #4209

Reaktionsgleichung

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

Ausbeute 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

Ausbeute 60.4%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction was filtered hot
2. 2
   Sonstigeto remove the sodium iodide
3. 3
   Sonstigea precipitate formed in the cold filtrate which
4. 4
   Sonstigewas collected
5. 5
   Waschenwashed with cold acetone
6. 6
   Sonstigeto give
7. 7
   Sonstigeupon drying

Vorschrift

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

Quelle