Reaktion #420432

Reaktionsgleichung

1-(4-fluorophenyl)cyclohexane-carboxylic acid

methylamine

→

amide

Ausbeute 86.0%

1-(4-fluorophenyl)-N-methylcyclohexanecarboxamide

Ausbeute 86.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product was purified by silica gel column chromatography

Vorschrift

The title compound was synthesized from 1-(4-fluorophenyl)cyclohexane-carboxylic acid (222 mg, 1 mmol) and methylamine (1 mL, 1M in THF, 1 eq) according to General Procedure G. The crude product was purified by silica gel column chromatography to give the amide (202.6 mg, 86%) as a white solid.

Quelle