Reaktion #42040

Reaktionsgleichung

t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate

→

3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoic acid

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step 5
2. 2
   Sonstigewere removed by filtration
3. 3
   workup.DISTILLATIONthe filtrate was distilled off under reduced pressure
4. 4
   Sonstigethe residue was crystallized from acetonitrile

Vorschrift

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate obtained in the step 5 was used, and that the resulting crude product was mixed with methanol, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized from acetonitrile.

Quelle