Reaktion #42038

Reaktionsgleichung

ethyl 4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoate

→

4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoic acid

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step 1
2. 2
   Sonstigeinsolubles were removed by filtration
3. 3
   workup.DISTILLATIONthe filtrate was distilled off under reduced pressure
4. 4
   Sonstigethe residue was crystallized
5. 5
   workup.ADDITIONby adding acetonitrile

Vorschrift

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that ethyl 4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoate obtained in the step 1 was used, and that the crude product was mixed with methanol and stirred, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized by adding acetonitrile.

Quelle