Reaktion #42036

Reaktionsgleichung

4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoic acid

thionyl chloride

→

4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoyl chloride hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step 3
2. 2
   workup.DISTILLATIONwas distilled off under reduced pressure
3. 3
   workup.ADDITIONthe operation of adding of toluene to the residue
4. 4
   Sonstigefollowed by azeotropic removal of thionyl chloride

Vorschrift

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoic acid obtained in the step 3 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated three times.

Quelle