Reaktion #41991

Reaktionsgleichung

3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

methyl chloroformate

→

title compound

Ausbeute 36.0%

[3-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-carbamic acid methyl ester

Ausbeute 36.0%

Lösungsmittel

ether

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwash with 1N aqueous hydrochloric acid (2×)
2. 2
   Trocknendry over anhydrous sodium sulfate
3. 3
   Filtrationfilter
4. 4
   Einengenconcentrate solution in vacuo
5. 5
   SonstigePurify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes

Vorschrift

Dissolve 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine (0.35 g, 1.19 mmol) in pyridine (3 ml). Add methyl chloroformate (0.10 ml, 1.31 mmol, 1.1 equivalents) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with 1N aqueous hydrochloric acid (2×), dry over anhydrous sodium sulfate, filter, and concentrate solution in vacuo. Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes to provide the title compound as a white solid (0.15 g, 36%). LC-MS m/z 353.1 (M++1).

Quelle