Reaktion #419609
ord-545e0b0acb5140a78d71ff0acb464d41
Reaktionsgleichung
6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid
L-valinol
→
title compound
Ausbeute 86.0%
N—((S)-1-Hydroxymethyl-2-methyl-propyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide
Ausbeute 86.0%
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.65 mmol) was converted, using L-valinol instead of 2-aminoethyl isopropylether, to the title compound (220 mg, 86%) which was obtained as a white solid. MS: m/e=394.2 [M−H]−.