Reaktion #41919

Reaktionsgleichung

magnesium

2-bromo-5-fluoro-1-(tetrahydropyran-2-yloxy)benzene

trimethyl borate

→

4-Fluoro-2-(tetrahydropyran-2-yloxy)benzeneboronic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe yield was 434.5 g (1.81 mol), and the product was obtained as a waxy solid which
2. 2
   Sonstigewas used in the following stage without further purification

Vorschrift

Procedure analogous to Example 6. Use of 48.6 g (2.00 mol) of magnesium, 510 g (1.85 mol) of 2-bromo-5-fluoro-1-(tetrahydropyran-2-yloxy)benzene and 241.6 ml (2.00 mol) of trimethyl borate. The yield was 434.5 g (1.81 mol), and the product was obtained as a waxy solid which contained varying proportions of boronic anhydrides and borinic acids and was used in the following stage without further purification.

Quelle