Reaktion #419126

Reaktionsgleichung

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

L-phenylalanine methylester hydrochloride

→

title compound

Ausbeute 88.0%

(S)-2-{[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester

Ausbeute 88.0%

Reaktionsbedingungen

Vorschrift

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (111 mg, 0.36 mmol) was converted, using L-phenylalanine methylester hydrochloride instead of 2-aminoethyl isopropylether, to the title compound (148 mg, 88%) which was obtained as a white solid. MS: m/e=470.1 [M−H]−.

Quelle