Reaktion #418676

ord-44e4e3e17d6d4bb9ba8dce819cf53006

Reaktionsgleichung

Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1
trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride
Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1
intermediate B
Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1
trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride
O=C(O)Cc1ccc2c(c1)OCO2
2-benzo[1,3]dioxol-5-yl-acetic acid
O=C(Cc1ccc2c(c1)OCO2)N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1
title compound
O=C(Cc1ccc2c(c1)OCO2)N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1
trans-2-Benzo[1,3]dioxol-5-yl-N-(4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexyl)-acetamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound, white solid (112 mg, 92%), MS (ISP) m/z=491.3 [(M+H)+], mp 209° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 2-benzo[1,3]dioxol-5-yl-acetic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08877778B2uspto-grants-2014_11