Reaktion #41842

ord-fa33aa04990b413da75cdd22ca1aab4e

Reaktionsgleichung

Cl.NNc1nncc2ccccc12
1-hydrazinophthalazine HCL
CC(C)=O
acetone
→
CC(C)=NN.NNc1nncc2ccccc12
1-hydrazinophthalazine acetone hydrazone

Edukte

Cl.NNc1nncc2ccccc12
1-hydrazinophthalazine HCL
CC(C)=O
acetone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto react for 1 hour
  2. 2
    SonstigeThe solvent is evaporated
  3. 3
    Sonstigethe slightly yellow material is dried in vacuo

Vorschrift

1-hydrazinophthalazine HCL (395 mg; 2 mmoles) is dissolved in 2.5 ml of acetone and allowed to react for 1 hour. The solvent is evaporated and the slightly yellow material is dried in vacuo to yield 411 mg of 1-hydrazinophthalazine acetone hydrazone. (99% of theoretical yield). [British Journal of Pharmacology 61: 345-349 (1977)]

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728133B2uspto-grants-2010_06