Reaktion #418386

Reaktionsgleichung

N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide

2,5-dimethoxyaniline

→

title compound

Ausbeute 97.0%

N-[3-(2,5-Dimethoxy-phenylamino)-quinoxalin-2-yl]-3-fluorobenzene sulfonamide

Ausbeute 97.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate obtained
2. 2
   Filtrationis filtered
3. 3
   Waschenwashed with EtOH

Vorschrift

N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide (125 mg, 0.4 mmole) and 2,5-dimethoxyaniline (170.4 mg, 1.1 mmole) are taken in 0.5 ml of EtOH and the resulting suspension is stirred at 100° C. in an orbital shaker, overnight. The precipitate obtained is filtered and washed with EtOH then ether to afford the title compound as a dark green solid (163 mg, 97%). HPLC (max plot) 96%, rt. 4.88 min. LC/MS: (ES+): 455.2.

Quelle