Reaktion #41820

Reaktionsgleichung

(4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone

maleic acid

→

title compound

(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone Bis-maleate Salt

Lösungsmittel

EtOH

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to room temperature for 15 h
2. 2
   TemperaturThe reaction mixture was cooled further to 0° C.
3. 3
   workup.STIRRINGwas then stirred for 2 h
4. 4
   FiltrationThe resulting precipitate was collected by suction filtration
5. 5
   Waschenwashed with cold EtOH (20 mL)
6. 6
   SonstigeThe wet solid was dried in a vacuum oven at 40° C. for 6 h

Vorschrift

To a solution of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone (3.0 g, 9.05 mmol) in absolute EtOH (20 mL) was added, via an addition funnel, a solution of maleic acid (3.3 g, 19.8 mmol) in absolute EtOH (20 mL) over 10 min. The resulting suspension was stirred at room temperature for 15 min, at 75° C. for 30 min, and was then allowed to cool to room temperature for 15 h. The reaction mixture was cooled further to 0° C. and was then stirred for 2 h. The resulting precipitate was collected by suction filtration and washed with cold EtOH (20 mL). The wet solid was dried in a vacuum oven at 40° C. for 6 h to yield the title compound as crude material, as a white solid.

Quelle