Reaktion #41811

Reaktionsgleichung

intermediate

Ethyl 2-(2-Formylamino-5-chlorothiazol-4-yl)-2-oxoacetate

NaOH

HCl

→

title intermediate

2-(2-Formylamino-5-chlorothiazol-4-yl)-2-oxoacetic Acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas then added
2. 2
   FiltrationAfter vigorous stirring, the resulting precipitate was filtered
3. 3
   Waschenwashed with a minimum amount of cold water and air
4. 4
   Sonstigedried

Vorschrift

To the intermediate from Step 1 (3.6 g, 13.7 mmol) was added 1M NaOH (30 mL, 30 mmol). The resulting suspension was stirred at room temperature for 2 hours (at which time the solution was clear) and 1M HCl (30 mL, 30 mmol) was then added, followed by 100 mL of water. After vigorous stirring, the resulting precipitate was filtered, washed with a minimum amount of cold water and air dried to afford the title intermediate as an off-white solid.

Quelle