Reaktion #418015

ord-9a1efe617e9941eab7eea8d90018e4c0

Reaktionsgleichung

COc1cc(O)ccc1Br
4-bromo-3-methoxy-phenol
CCCBr
1-bromopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CCCOc1ccc(Br)c(OC)c1
1-Bromo-2-methoxy-4-propoxybenzene

Edukte

COc1cc(O)ccc1Br
4-bromo-3-methoxy-phenol
CCCBr
1-bromopropane
O=C([O-])[O-].[K+].[K+]
K2CO3

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF
O
water

Reaktionsbedingungen

Temperatur
80°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Extraktionextracted with DCM
  2. 2
    TrocknenThe organic layer is dried over sodium sulphate
  3. 3
    Sonstigethe solvent is removed in vacuo

Vorschrift

1.50 g (7.39 mmol) 4-bromo-3-methoxy-phenol are added to 1.36 g (11.1 mmol) 1-bromopropane in 10 mL DMF. 2.04 g (14.8 mmol) K2CO3 are added and the mixture is stirred at 80° C. for 12 h. After that time, the mixture is diluted with water and extracted with DCM. The organic layer is dried over sodium sulphate and the solvent is removed in vacuo.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08877754B2uspto-grants-2014_11